Monday Night Football: Carolina Panthers vs San Francisco 49ers

We’ve got one game left for Week 12 of the 2025/’26 NFL season. This week’s Monday Night Football features the Carolina Panthers visiting the San Francisco 49ers. The Panthers have been better than expected this season, and are only a game behind the Niners in the NFC. They are half a game behind the Buccaneers in the NFC South, while San Francisco is sitting in 3rd place in the NFC West. Big game for both teams looking to make a playoff run this year.

Who: Carolina Panthers (6-5) at San Francisco 49ers (7-4)

Where: Levi’s Stadium | Santa Clara, CA

When: November 24, 2025, 8:15 p.m.

TV: ABC/ESPN

Joe Buck (play-by-play)

Troy Aikman (analyst)

Lisa Salters (sideline)

ManningCast on ESPN2

Sirius XM NFL

Carolina: XM/SXM 226, Internet 804

San Francisco: XM/SXM 225, Internet 827

National: 88

Español: XM/SXM 227, Internet 832

Online Stream: Fubo.TV, ESPN+

FanDuel Sportsbook odds: 49ers -7.5, 49.5 O/U

Carolina: +320

San Francisco: -405

Prediction: 49ers 33 – Panthers 20

SB Nation Blogs: Cat Scratch Reader | Niners Nation

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