Monday Night Football Odds: MNF Betting Lines 2025

The Week 12 finale features an unlikely "potential playoff" matchup as the Carolina Panthers visit the San Francisco 49ers.

Carolina sits at a surprising 6-5 on the season, but the NFL odds have it as a 6.5-point road dog against a 7-4 San Fran squad that just got back its star QB.

Check out our latest Monday Night Football odds, MNF player props, and the full NFL Monday schedule for 2025 ahead of this prime-time clash.

Monday Night Football odds

Panthers vs 49ers opening odds

• Point spread: Panthers +6.5 | 49ers -6.5

• Moneyline: Panthers +240 | 49ers -300

• Total: Over 45.5 | Under 45.5

Panthers vs 49ers player props

Panthers vs 49ers passing props

View all MNF passing props, including Bryce Young odds and Brock Purdy odds.

Panthers vs 49ers rushing props

View all MNF rushing props, including Rico Dowdle odds and Christian McCaffrey odds.

Panthers vs 49ers receiving props

View all MNF receiving props, including Tetairoa McMillan odds and George Kittle odds.

Panthers vs 49ers touchdown props

More Panthers vs 49ers picks from Covers

• Panthers vs. 49ers predictions

• Panthers vs. 49ers props

• Panthers vs. 49ers same-game parlay

• Panthers vs. 49ers anytime touchdown scorer picks

• Christian McCaffrey odds and props

Monday Night Football 2025 schedule & how to watch

Date

Matchup

Time

9/8Week 1

Vikings (27) at Bears (24)

8:15ESPN/ABC

9/15Week 2

Buccaneers (20) at Texans (19)

7:00ESPN/ABC

9/15Week 2

Chargers (20) at Raiders (9)

10:00ESPN

9/22Week 3

Lions (38) at Ravens (30)

8:15ESPN/ABC

9/29Week 4

Jets (21) at Dolphins (27)

7:15ESPN

9/29Week 4

Bengals (3) at Broncos (28)

8:15ABC

10/6Week 5

Chiefs (28) at Jaguars (31)

8:15ESPN/ABC

10/13Week 6

Bills (14) at Falcons (24)

7:15ESPN

10/13Week 6

Bears (25) at Commanders (24)

8:15ABC

10/20Week 7

Buccaneers (9) at Lions (24)

7:00ESPN/ABC

10/20Week 7

Texans (19) at Seahawks (27)

10:00ESPN+

10/28Week 8

Commanders (7) at Chiefs (28)

8:15ESPN/ABC

11/3Week 9

Cardinals (27) at Cowboys (17)

8:15ESPN/ABC

11/10Week 10

Eagles (10) at Packers (7)

8:15ESPN/ABC

11/17Week 11

Cowboys (33) at Raiders (16)

8:15ESPN/ABC

11/24Week 12

Panthers at 49ers

8:15ESPN

12/1Week 13

Giants at Patriots

8:15ESPN

12/8Week 14

Eagles at Chargers

8:15ESPN/ABC

12/15Week 15

Dolphins at Steelers

8:15ESPN

12/22Week 16

49ers at Colts

8:15ESPN

12/29Week 17

Rams at Falcons

8:15ESPN

No MNF matchup for Week 18

MNF betting tips

From Jason Logan, Covers Senior Industry Analyst

1

Time to heal

The polar opposite of one of my TNF betting tips, Monday games leave players with more time to nurse any wounds. Injured players have an extra day for recovery and often will wait until the 11th hour to make a decision.

2

What happens next?

Monday games present a shorter schedule for the teams involved, falling one day behind the usual cadence in preparing for the upcoming week. While not as drastic as navigating a Thursday game, teams may have to forfeit either an early-week walkthrough or a rest day in order to stay on schedule. Look at the teams’ upcoming schedule and see if this later finish week leads to more problems ahead — especially for the road team, which also needs to factor in travel.

3

Home-field frenzy

The veracity of the home can get ramped up on prime-time games. Instead of the usual tailgating duration for a 1 p.m. or 4 p.m. game, the home crowd instead gets to party all day long. That juiced-up crowd is then released into the stadium — and unleashed onto the visitors — giving the home hospitality a little extra bite.

4

Cold concerns

Monday nighters can also be an advantage for cold weather teams come December and January. Temperatures plummet when the sun goes down and places like Buffalo, Foxborough, and East Rutherford can turn into frozen wastelands. While both sides feel the chill of the low temps, visitors from warmer cities or indoor stadiums may struggle to adapt when the mercury drops.

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This article originally appeared on Covers.com, read the full article here