Panthers Week 12 inactives: New OL combo, starting LBs vs. 49ers

Limiting San Francisco 49ers running back Christian McCaffrey is an extremely difficult task as it is. And unfortunately for the Carolina Panthers, they'll have to try to do it without a few of their defensive starters.

As announced on Saturday, inside linebackers Trevin Wallace and Christian Rozeboom have been ruled out of tonight's contest at Levi's Stadium. Wallace will miss his second straight game with a shoulder injury while Rozeboom, who made an early exit from last week's win over the Atlanta Falcons, is sidelined due to hip and hamstring issues.

The Panthers, in their places, are expected to start Claudin Cherelus and sixth-year veteran Krys Barnes—who was elevated from the practice squad earlier this afternoon.

Carolina will also be without starting center Cade Mays, who sustained an ankle injury during practice on Friday. Austin Corbett will get the nod in his stead, making for the team's ninth different combination of their starting offensive line in 12 games.

Here is the full list of inactives on the night for the Panthers:

• WR Hunter Renfrow

• TE James Mitchell

• C Cade Mays

• DL Jared Harrison-Hunte

• DL Cam Jackson

• ILB Christian Rozeboom

• ILB Trevin Wallace

And for the host 49ers:

• RB Jordan James

• WR Jordan Watkins

• OL Connor Colby

• DL Robert Beal Jr.

• DL Kevin Givens

• LB Tatum Bethune

• K Eddy Piñeiro

Follow @ThePanthersWire on Twitter/X for more Panthers content.

This article originally appeared on Panthers Wire: Panthers Week 12 inactives: New OL combo, starting LBs vs. 49ers