Week 13 picks: Who the experts are taking in Texans vs. Colts

Week 13 picks: Who the experts are taking in Texans vs. ColtsStory byCole Thompson, Texans WireFri, November 28, 2025 at 6:21 PM UTC·2 min read

How does C.J. Stroud respond after missing the past three weeks?

The Houston Texans (6-5) hit the road to take on the Indianapolis Colts (8-3) at Lucas Oil Stadium in Week 13, which could have massive implications on who wins the AFC South division title. Houston is riding high on a three-game win streak, while the Colts have lost two of their last three games with late comebacks.

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Sunday will mark the first meeting meeting between the two AFC South foes and begin the 2025 bout between the two sides, who could be the favorites to win the division. Last season, Houston bested the Colts twice en route to a second straight division title, including a promising Week 1 performance from C.J. Stroud and running back Joe Mixon.

Getting the call for this game are Chris Myers (play-by-play), Mark Schlereth (analyst), and Jen Hale (sideline reporter).

The Texans are a 3.5-point road underdog against the Colts, according to BetMGM. But what do the experts think? Here's a look around the league on who they think will win on Sunday at Lucas Oil Stadium:

Nov 2, 2025; Houston, Texas, USA; Houston Texans quarterback C.J. Stroud (7) hands off to running back Nick Chubb (21) during the first half against the Denver Broncos at NRG Stadium. Mandatory Credit: Thomas Shea-Imagn Images

USA Today

• Michael Middlehurst-Schwartz: Texans

• Jarrett Bell: Texans

• Nick Brinkerhoff: Titans

• Chris Bumbaca: Texans

• Nate Davis: Texans

• Tyler Dragon: Colts

Oct 5, 2025; Baltimore, Maryland, USA; Houston Texans running back Nick Chubb (21) runs for a gain past Baltimore Ravens cornerback Keyon Martin (38) during the third quarter at M&T Bank Stadium. Mandatory Credit: Rafael Suanes-Imagn Images

NFL.com

• Ali Bhanpuri: Colts

• Brooke Cersosimo: Colts

• Dan Parr: Texans

• Gennaro Filice: Colts

• Tom Blair: Texans

Nov 2, 2025; Houston, Texas, USA; Houston Texans wide receiver Nico Collins (12) makes a catch against Denver Broncos cornerback Riley Moss (21) during the first half at NRG Stadium. Mandatory Credit: Thomas Shea-Imagn Images

ESPN

• Stephania Bell: Colts

• Matt Bowen: Texans

• Mike Clay: Colts

• Jeremy Fowler: Texans

• Dan Graziano: Texans

• Kalyn Kahler: Colts

• Pamela Maldonado: Colts

• Eric Moody: Colts

• Jason Reid: Colts

• Lindsey Thiry: Colr

• Sam Wickersham: Texans

Nov 2, 2025; Houston, Texas, USA; Houston Texans head coach DeMeco Ryans during the first half against the Denver Broncos at NRG Stadium. Mandatory Credit: Thomas Shea-Imagn Images

CBS Sports

• Pete Prisco: Colts

• Cody Benjamin: Texans

• Jared Dubin: Colts

• Ryan Wilson: Colts

• John Breech: Texans

• Tyler Sullivan: Colts

• Dave Richard: Texans

• Jamey Eisenberg: Texans

Nov 2, 2025; Houston, Texas, USA; Houston Texans running back Woody Marks (27) runs against Denver Broncos linebacker Que Robinson (51) and safety Talanoa Hufanga (9) during the second half at NRG Stadium. Mandatory Credit: Thomas Shea-Imagn Images

MMQB

• Albert Breer: Colts

• Clare Brennan: Colts

• Mitch Goldich: Texans

• Gilberto Manzano: Texans

• Conor Orr: Colts

• John Pluym: Colts

• Matt Verderame: Texans

Nov 2, 2025; Houston, Texas, USA; Houston Texans safety Calen Bullock (2) celebrates after an interception during the first half Denver Broncos at NRG Stadium. Mandatory Credit: Thomas Shea-Imagn Images

Bleacher Report

• Gary Davenport: Texans

• Brad Gagnon: Texans

• Ian Hanford: Texans

• Kris Knox: Texans

• Maurice Moton: Texans

• Wes O’Donnell: Colts

• Brent Sobleski: Texans

Aug 16, 2025; Houston, Texas, USA; Houston Texans cornerback Derek Stingley Jr. (24) runs with the ball during the first quarter against the Carolina Panthers at NRG Stadium. Mandatory Credit: Troy Taormina-Imagn Images

Texans Wire

Cole Thompson: Texans

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This article originally appeared on Texans Wire: Texans vs. Colts: Experts make picks for Sunday's Week 11 game

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